Positive regulation of post-transcriptional gene silencing

Across TCGA patient cohorts, RNA activity of the Positive regulation of post-transcriptional gene silencing pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AJUBA_S137, SF3B3, and MLYCD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of post-transcriptional gene silencing activity versus AJUBA_S137 in BRCA (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AJUBA_S137 →	+0.918	+0.041	<.001	.006	3	5
COAD	SF3B3 →	+0.163	+0.029	<.001	.001	3	4
OV	MLYCD →	-0.384	-0.041	<.001	.004	2	5
UCEC	GMDS_S14 →	-0.610	-0.075	.001	<.001	3	4
UCEC	ATP5IF1 →	-0.615	-0.074	<.001	<.001	3	4
PDAC	SPON2 →	+0.796	+0.050	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060148 vs AJUBA_S137 — BRCA

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