Positive regulation of post-transcriptional gene silencing

Across TCGA patient cohorts, RNA activity of the Positive regulation of post-transcriptional gene silencing pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNMA1-AS3, KCNMA1, and KCNMA1-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of post-transcriptional gene silencing activity versus KCNMA1-AS3 in UCEC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCNMA1-AS3 →	-0.693	-0.233	.005	.002	3	4
GBM	KCNMA1 →	-0.550	-0.442	<.001	<.001	3	4
CCRCC	KCNMA1-AS1 →	-0.443	-0.601	.003	.002	3	3
PDAC	YWHAZP2 →	+0.419	+0.535	.002	<.001	3	3
HNSC	PRKCQ-AS1 →	-0.872	-0.344	<.001	.001	3	3
BRCA	NOP56 →	+0.305	+0.489	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060148 vs KCNMA1-AS3 — UCEC

Explore this scatter interactively →