Positive regulation of post-transcriptional gene silencing

Across TCGA cell cohorts, RNA activity of the Positive regulation of post-transcriptional gene silencing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF5, JPT1, and HCFC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of post-transcriptional gene silencing activity versus TAF5 in BLOOD_Lymphoma (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TAF5 →	+0.512	+0.709	.003	.003	3	6
BLOOD_Leukemia	JPT1 →	+0.692	+0.767	.003	.001	3	4
BREAST	HCFC1 →	+0.565	+0.685	.005	.003	2	5
SOFT_TISSUE	CBLB →	+3.357	+1.501	.001	.008	3	4
STOMACH	MSH6 →	+1.234	+1.377	.001	.001	3	4
LUNG_NSCLC_LUAD	KIF4B →	+0.056	+0.647	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060148 vs TAF5 — BLOOD_Lymphoma

Explore this scatter interactively →