Positive regulation of syncytium formation by plasma membrane fusion

Across TCGA cell cohorts, RNA activity of the Positive regulation of syncytium formation by plasma membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KMT5C, CAV1, and RAB32, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KMT5C grouped by Positive regulation of syncytium formation by plasma membrane fusion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KMT5C →	+1.600	+1.560	.002	<.001	3	5
OVARY	CAV1 →	-2.937	-1.086	.003	.003	3	5
BREAST	RAB32 →	-1.387	-0.645	.004	.009	2	6
LUNG_SCLC	PMP22 →	-3.153	-1.268	<.001	<.001	3	4
LUNG_NSCLC_LUSC	RMND5A →	+1.445	+1.403	.004	.001	3	4
LUNG_SCLC	BICDL1 →	+2.317	+1.222	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KMT5C by Positive regulation of syncytium formation by plasma membrane fusion activity — LUNG_SCLC

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