Regulation of syncytium formation by plasma membrane fusion

Across TCGA patient cohorts, RNA activity of the Regulation of syncytium formation by plasma membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR8, LILRB1, and MS4A6A, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of syncytium formation by plasma membrane fusion activity versus TLR8 in LAML (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	TLR8 →	+2.053	+0.050	<.001	<.001	3	33
SCLC	LILRB1 →	+1.603	+0.154	<.001	<.001	3	33
LAML	MS4A6A →	+2.255	+0.054	<.001	<.001	3	33
SCLC	IL10RA →	+1.904	+0.202	<.001	<.001	3	33
SCLC	CD86 →	+2.812	+0.137	<.001	<.001	3	33
LAML	LILRB2 →	+2.204	+0.058	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060142 vs TLR8 — LAML

Explore this scatter interactively →