Regulation of syncytium formation by plasma membrane fusion

Across TCGA patient cohorts, RNA activity of the Regulation of syncytium formation by plasma membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G2D, SIT1, and TRBV7-3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of syncytium formation by plasma membrane fusion activity versus PLA2G2D in LSCC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLA2G2D →	+1.035	+0.571	<.001	<.001	3	6
LSCC	SIT1 →	+0.695	+0.503	<.001	<.001	3	6
OV	TRBV7-3 →	+0.620	+0.525	.005	.009	3	5
HNSC	CD2 →	+1.084	+0.403	.002	.001	3	5
HNSC	CD48 →	+0.950	+0.433	<.001	.001	3	5
CCRCC	GBP5 →	+1.200	+0.470	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060142 vs PLA2G2D — LSCC

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