Regulation of syncytium formation by plasma membrane fusion

Across TCGA cell cohorts, RNA activity of the Regulation of syncytium formation by plasma membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRSK1, HDGF, and GDPD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRSK1 grouped by Regulation of syncytium formation by plasma membrane fusion-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BRSK1 →	+2.102	+0.412	<.001	<.001	3	5
STOMACH	HDGF →	-0.562	-0.350	<.001	.002	3	4
STOMACH	GDPD1 →	+1.596	+0.454	.003	.002	3	4
OESOPHAGUS	BRSK2 →	+1.861	+0.383	<.001	<.001	3	4
SKIN	RNMT →	+0.526	+0.324	<.001	<.001	3	4
BLOOD_Lymphoma	C7orf61 →	+0.829	+0.680	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRSK1 by Regulation of syncytium formation by plasma membrane fusion activity — OESOPHAGUS

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