Regulation of syncytium formation by plasma membrane fusion

Across TCGA cell cohorts, RNA activity of the Regulation of syncytium formation by plasma membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOMM40L, MT-ND4, and COTL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of syncytium formation by plasma membrane fusion activity versus TOMM40L in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TOMM40L →	+0.684	+0.186	.006	.007	3	6
LARGE_INTESTINE	MT-ND4 →	-0.672	-0.172	.003	.001	3	5
PANCREAS	COTL1 →	+1.054	+0.202	.003	.003	3	4
CNS	ATL3 →	+0.820	+0.202	.006	.001	3	4
SOFT_TISSUE	DIDO1 →	-0.782	-0.153	.004	<.001	3	4
URINARY_TRACT	LONRF3 →	+1.884	+0.293	.003	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060142 vs TOMM40L — UPPER_AERODIGESTIVE_TRACT

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