Maternal process involved in female pregnancy

Across TCGA patient cohorts, RNA activity of the Maternal process involved in female pregnancy pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRTAP, PLAU, and C1QC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maternal process involved in female pregnancy activity versus CRTAP in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CRTAP →	+0.640	+0.056	<.001	<.001	3	8
GBM	PLAU →	+0.813	+0.054	<.001	<.001	3	8
GBM	C1QC →	+0.735	+0.046	<.001	.001	3	8
PDAC	PPP1R18_S224 →	+0.424	+0.028	<.001	<.001	3	7
BRCA	THBS1 →	+1.006	+0.050	<.001	<.001	3	7
LSCC	BMP1 →	+0.676	+0.051	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060135 vs CRTAP — OV

Explore this scatter interactively →