Maternal process involved in female pregnancy

Across TCGA patient cohorts, RNA activity of the Maternal process involved in female pregnancy pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENO2, GBE1, and SPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maternal process involved in female pregnancy activity versus ENO2 in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ENO2 →	+0.751	+0.218	.002	.003	3	6
BRCA	GBE1 →	+0.675	+0.403	.001	.002	3	6
HNSC	SPP1 →	+1.887	+0.524	<.001	<.001	3	6
LSCC	LY9 →	-0.791	-0.293	<.001	.001	3	6
PDAC	P4HA1 →	+0.499	+0.314	<.001	<.001	3	6
PDAC	LOXL2 →	+0.912	+0.429	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060135 vs ENO2 — LSCC

Explore this scatter interactively →