Maternal process involved in female pregnancy

Across TCGA cell cohorts, RNA activity of the Maternal process involved in female pregnancy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD82, FLNA, and HERPUD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD82 grouped by Maternal process involved in female pregnancy-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD82 →	-3.122	-0.899	<.001	.006	3	5
LIVER	FLNA →	-2.428	-1.625	.006	<.001	3	4
LIVER	HERPUD2 →	-0.613	-1.249	.001	.005	3	4
LIVER	SLC5A6 →	+1.305	+1.231	<.001	<.001	3	4
LIVER	PPP1R18 →	-2.813	-1.270	.003	.008	3	4
BLOOD_Myeloma	LY96 →	-3.105	-0.842	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD82 by Maternal process involved in female pregnancy activity — BLOOD_Leukemia

Explore this box plot interactively →