Maternal process involved in female pregnancy

Across TCGA cell cohorts, RNA activity of the Maternal process involved in female pregnancy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUS1, STC2, and PGAM5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maternal process involved in female pregnancy activity versus PUS1 in BLOOD_Myeloma (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PUS1 →	-0.913	-0.125	.007	.009	3	8
BONE	STC2 →	+4.761	+0.198	<.001	<.001	3	8
BLOOD_Lymphoma	PGAM5 →	-0.977	-0.118	<.001	<.001	3	8
BONE	NRP1 →	+3.474	+0.178	<.001	<.001	3	7
BLOOD_Lymphoma	NCL →	-0.732	-0.073	<.001	<.001	3	7
BONE	ITGA5 →	+2.327	+0.178	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060135 vs PUS1 — BLOOD_Myeloma

Explore this scatter interactively →