Maternal process involved in female pregnancy

Across TCGA cell cohorts, RNA activity of the Maternal process involved in female pregnancy pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP2C2, SIRT1, and ADCK5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maternal process involved in female pregnancy activity versus ATP2C2 in LUNG_NSCLC_LUSC (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ATP2C2 →	-2.150	-0.149	.001	.009	3	5
SOFT_TISSUE	SIRT1 →	+0.686	+0.184	.001	.009	3	5
LUNG_SCLC	ADCK5 →	-1.067	-0.164	.002	<.001	3	5
LUNG_NSCLC_LUAD	SRGAP2 →	+1.028	+0.157	<.001	<.001	3	4
SOFT_TISSUE	PAPSS1 →	+1.295	+0.277	.002	.001	3	4
STOMACH	SLC16A10 →	+1.324	+0.253	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060135 vs ATP2C2 — LUNG_NSCLC_LUSC

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