Prepulse inhibition

Across TCGA patient cohorts, RNA activity of the Prepulse inhibition pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SECISBP2, PABPN1, and LINC01460, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prepulse inhibition activity versus SECISBP2 in COAD (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SECISBP2 →	+0.309	+0.309	.001	.007	3	4
LSCC	PABPN1 →	+0.429	+0.959	<.001	<.001	3	4
LSCC	LINC01460 →	-0.480	-0.763	.002	.006	3	3
LSCC	P3H2 →	-0.730	-0.525	.005	.006	3	3
CCRCC	QPRT →	-0.728	-0.193	.009	.005	3	3
CCRCC	PLPP7 →	+0.484	+0.227	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060134 vs SECISBP2 — COAD

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