Prepulse inhibition

Across TCGA cell cohorts, RNA activity of the Prepulse inhibition pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3HC1, KIAA1549L, and GRIK5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZC3HC1 grouped by Prepulse inhibition-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZC3HC1 →	-0.300	-0.230	.004	.001	3	4
PANCREAS	KIAA1549L →	-0.210	-0.145	.002	.002	3	4
OESOPHAGUS	GRIK5 →	-0.142	-0.195	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	OCLN →	-0.226	-0.110	<.001	.003	3	4
BREAST	SET →	+0.131	+0.472	<.001	.001	3	3
BLOOD_Myeloma	RBPMS →	+0.484	+0.210	.001	.005	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZC3HC1 by Prepulse inhibition activity — BLOOD_Myeloma

Explore this box plot interactively →