Auditory receptor cell development

Across TCGA patient cohorts, RNA activity of the Auditory receptor cell development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLMN_S619, SEC22B_S168, and ATP1B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Auditory receptor cell development activity versus CLMN_S619 in LUAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CLMN_S619 →	+0.871	+0.050	<.001	<.001	3	5
COAD	SEC22B_S168 →	+0.355	+0.030	.001	<.001	3	4
COAD	ATP1B1 →	+0.509	+0.047	.002	<.001	3	4
COAD	SPAG1 →	+0.652	+0.040	<.001	<.001	3	4
COAD	TSPAN15 →	+0.406	+0.032	.001	.009	3	4
HNSC	FOXA1_S331 →	+0.741	+0.040	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060117 vs CLMN_S619 — LUAD

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