Auditory receptor cell development

Across TCGA cell cohorts, RNA activity of the Auditory receptor cell development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF13, KDM1A, and RCOR1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF13 grouped by Auditory receptor cell development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KLF13 →	-0.197	-0.904	<.001	.001	3	3
BREAST	KDM1A →	-0.355	-0.724	.004	.002	3	3
BREAST	RCOR1 →	-0.155	-0.604	<.001	.001	3	3
BLOOD_Leukemia	ARSJ →	+0.135	+0.320	.001	.003	3	3
OESOPHAGUS	WNT7A →	+0.125	+0.328	.002	<.001	3	3
OESOPHAGUS	CEL →	+0.201	+0.343	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF13 by Auditory receptor cell development activity — BREAST

Explore this box plot interactively →