Membrane hyperpolarization

Across TCGA patient cohorts, RNA activity of the Membrane hyperpolarization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC9A3R2, LTBP4, and MIA3_S876, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane hyperpolarization activity versus SLC9A3R2 in CCRCC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC9A3R2 →	-0.414	-0.042	<.001	<.001	3	5
CCRCC	LTBP4 →	-0.564	-0.035	.002	.005	3	5
GBM	MIA3_S876 →	+0.527	+0.048	<.001	.003	3	5
BRCA	MIA3_S727 →	+0.564	+0.047	.001	<.001	3	5
LSCC	SH3BP4 →	-0.300	-0.060	.002	<.001	3	5
CCRCC	SLC12A8_T485 →	+2.286	+0.073	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060081 vs SLC9A3R2 — CCRCC

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