Membrane hyperpolarization

Across TCGA cell cohorts, RNA activity of the Membrane hyperpolarization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEBL, CCDC102A, and CDH13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEBL grouped by Membrane hyperpolarization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NEBL →	+3.108	+1.358	.003	.003	2	5
SKIN	CCDC102A →	-0.867	-1.052	.004	.001	3	4
SKIN	CDH13 →	-2.008	-0.872	.005	.002	3	4
SKIN	CCN1 →	-2.255	-1.230	<.001	<.001	3	4
SOFT_TISSUE	PTPN14 →	-1.292	-1.459	.003	.001	3	4
SOFT_TISSUE	GPR176 →	-3.342	-1.429	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEBL by Membrane hyperpolarization activity — SOFT_TISSUE

Explore this box plot interactively →