Inhibitory postsynaptic potential

Across TCGA patient cohorts, RNA activity of the Inhibitory postsynaptic potential pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD48, EVI2A, and CCR5, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inhibitory postsynaptic potential activity versus CD48 in SCLC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CD48 →	-2.061	-1.084	<.001	<.001	3	26
SCLC	EVI2A →	-1.479	-0.665	<.001	<.001	3	26
SCLC	CCR5 →	-2.111	-0.715	.001	<.001	3	26
SCLC	CCL4 →	-1.541	-0.659	.001	.003	3	26
PCPG	CD300A →	-1.127	-0.037	<.001	<.001	3	25
SCLC	CLEC4A →	-1.686	-0.764	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060080 vs CD48 — SCLC

Explore this scatter interactively →