Inhibitory postsynaptic potential

Across TCGA cell cohorts, RNA activity of the Inhibitory postsynaptic potential pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAE1, PARD6G, and MRPS15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAE1 grouped by Inhibitory postsynaptic potential-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RAE1 →	+0.346	+0.957	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PARD6G →	+0.097	+0.846	.007	.005	3	4
CNS	MRPS15 →	+0.185	+2.207	.003	.003	3	4
BONE	INCA1 →	+0.374	+1.910	.002	<.001	3	3
BONE	CCL26 →	+0.335	+1.888	<.001	<.001	3	3
LUNG_NSCLC_LUAD	PILRA →	+0.085	+0.822	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAE1 by Inhibitory postsynaptic potential activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →