Regulation of postsynaptic membrane potential

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic membrane potential pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPFIBP2_S387, UBLCP1, and SULT1B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic membrane potential activity versus PPFIBP2_S387 in LSCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPFIBP2_S387 →	-0.316	-0.015	<.001	<.001	3	5
BRCA	UBLCP1 →	-0.222	-0.022	<.001	.001	3	5
COAD	SULT1B1 →	-0.546	-0.011	.001	.004	3	4
COAD	COL18A1 →	-0.391	-0.017	<.001	.003	3	4
COAD	CTIF →	-0.466	-0.018	.002	.001	3	4
BRCA	RSU1 →	-0.349	-0.022	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060078 vs PPFIBP2_S387 — LSCC

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