Regulation of postsynaptic membrane potential

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDNRB, SENCR, and CRISPLD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic membrane potential activity versus EDNRB in UCEC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EDNRB →	+0.774	+0.716	.001	.001	3	6
LSCC	SENCR →	+0.561	+0.772	<.001	.001	3	6
UCEC	CRISPLD2 →	+0.975	+0.845	<.001	<.001	3	5
CCRCC	IL1RL1 →	+0.971	+0.811	.002	<.001	3	5
UCEC	F10 →	+0.818	+0.704	.001	.006	3	5
UCEC	CAVIN2 →	+1.076	+0.739	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060078 vs EDNRB — UCEC

Explore this scatter interactively →