Regulation of resting membrane potential

Across TCGA cell cohorts, RNA activity of the Regulation of resting membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP9, AOX1, and RIBC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP9 grouped by Regulation of resting membrane potential-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DUSP9 →	+0.608	+0.761	<.001	.001	3	5
LIVER	AOX1 →	-3.454	-1.707	.004	.009	3	5
OVARY	RIBC1 →	+0.677	+1.216	.008	.003	2	5
KIDNEY	SMURF2 →	-1.148	-1.178	<.001	<.001	3	4
CNS	CSPG5 →	+1.044	+0.811	<.001	<.001	3	4
BLOOD_Lymphoma	MPRIP →	-1.402	-1.798	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP9 by Regulation of resting membrane potential activity — CNS

Explore this box plot interactively →