Regulation of resting membrane potential

Across TCGA cell cohorts, RNA activity of the Regulation of resting membrane potential pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPA13, WDFY1, and RNASE12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSPA13 grouped by Regulation of resting membrane potential-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HSPA13 →	+0.169	+1.568	.006	.003	2	5
LUNG_SCLC	WDFY1 →	+0.250	+1.406	<.001	<.001	3	3
BREAST	RNASE12 →	+0.115	+0.612	.007	.007	3	3
BREAST	HACD3 →	+0.193	+0.906	.001	<.001	3	3
LUNG_NSCLC_LUSC	HAUS6 →	+0.545	+1.522	<.001	<.001	3	3
LUNG_NSCLC_LUSC	TTC32 →	+0.282	+1.409	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSPA13 by Regulation of resting membrane potential activity — OVARY

Explore this box plot interactively →