Vagina development

Across TCGA patient cohorts, RNA activity of the Vagina development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PABPC1, RPS12, and SRP68, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vagina development activity versus PABPC1 in OV (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PABPC1 →	-0.270	-0.047	.003	.005	3	6
BRCA	RPS12 →	-0.249	-0.058	.001	.001	3	6
BRCA	SRP68 →	-0.277	-0.047	<.001	.006	3	6
BRCA	AKAP12_S248 →	+0.506	+0.051	.006	.001	3	6
OV	FYCO1 →	+0.296	+0.060	.001	.003	3	5
BRCA	RPS13 →	-0.203	-0.044	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060068 vs PABPC1 — OV

Explore this scatter interactively →