Uterus development

Across TCGA patient cohorts, RNA activity of the Uterus development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS30, SPATA24, and ENO4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Uterus development activity versus MRPS30 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRPS30 →	+1.280	+0.559	<.001	<.001	3	5
BRCA	SPATA24 →	+0.611	+0.537	<.001	<.001	3	5
HNSC	ENO4 →	+0.457	+0.556	.009	.004	2	5
BRCA	PCBD2 →	+0.464	+0.612	<.001	<.001	3	4
LSCC	IQCC →	+0.491	+0.635	<.001	.003	3	4
BRCA	TIGD6 →	+0.369	+0.520	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060065 vs MRPS30 — BRCA

Explore this scatter interactively →