Uterus development

Across TCGA cell cohorts, RNA activity of the Uterus development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C12orf66, TMTC4, and MLKL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C12orf66 grouped by Uterus development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf66 →	+0.722	+1.492	<.001	<.001	3	5
OVARY	TMTC4 →	-0.629	-1.354	.004	<.001	3	4
OVARY	MLKL →	+2.169	+1.332	<.001	<.001	3	4
OVARY	LRIT3 →	-0.126	-1.097	.001	.006	3	4
CNS	TUBB2B →	-2.091	-0.867	.003	.009	3	4
CNS	COLQ →	-0.470	-1.171	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C12orf66 by Uterus development activity — OVARY

Explore this box plot interactively →