Embryonic retina morphogenesis in camera-type eye

Across TCGA patient cohorts, RNA activity of the Embryonic retina morphogenesis in camera-type eye pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAU, SETMAR, and ALOX5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic retina morphogenesis in camera-type eye activity versus PLAU in PDAC (Pearson r = -0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLAU →	-0.687	-0.075	<.001	.006	3	7
BRCA	SETMAR →	+0.293	+0.080	<.001	<.001	3	6
CCRCC	ALOX5 →	-0.625	-0.150	<.001	<.001	3	6
GBM	THYN1 →	+0.410	+0.110	<.001	.001	3	6
GBM	TSN →	+0.208	+0.104	.004	.001	3	6
PDAC	RPS2_S264 →	-0.790	-0.085	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060059 vs PLAU — PDAC

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