Embryonic retina morphogenesis in camera-type eye

Across TCGA patient cohorts, RNA activity of the Embryonic retina morphogenesis in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROX1, PROX1-AS1, and ASPH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic retina morphogenesis in camera-type eye activity versus PROX1 in UCEC (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PROX1 →	+2.188	+0.504	<.001	.001	3	6
GBM	PROX1-AS1 →	+0.404	+0.266	.001	<.001	3	6
PDAC	ASPH →	-0.406	-0.450	.008	.005	3	5
BRCA	RALB →	-0.777	-0.227	<.001	<.001	3	5
UCEC	TNFRSF11B →	+1.232	+0.336	.003	.007	3	4
BRCA	GPR160 →	-1.696	-0.230	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060059 vs PROX1 — UCEC

Explore this scatter interactively →