Embryonic retina morphogenesis in camera-type eye

Across TCGA patient cohorts, RNA activity of the Embryonic retina morphogenesis in camera-type eye pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PROX1_S179, PROX1_S511, and PROX1_S199, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic retina morphogenesis in camera-type eye activity versus PROX1_S179 in BRCA (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PROX1_S179 →	+1.495	+0.462	<.001	<.001	3	7
BRCA	PROX1_S511 →	+1.461	+0.342	<.001	<.001	3	7
BRCA	PROX1_S199 →	+1.840	+0.504	.001	.001	2	5
LSCC	PROX1_S295 →	+1.856	+0.873	<.001	.001	3	3
LSCC	SH3BP2_S444 →	+0.488	+0.285	.001	.002	3	2
PDAC	SIPA1L1_S1603 →	-0.575	-0.601	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060059 vs PROX1_S179 — BRCA

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