Embryonic retina morphogenesis in camera-type eye

Across TCGA cell cohorts, RNA activity of the Embryonic retina morphogenesis in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIPK2, HIPK1, and CHCHD3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic retina morphogenesis in camera-type eye activity versus HIPK2 in BLOOD_Lymphoma (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HIPK2 →	+2.316	+0.347	<.001	<.001	3	13
BREAST	HIPK1 →	+0.938	+0.708	.003	.003	3	9
BREAST	CHCHD3 →	+0.485	+0.483	.008	.006	3	8
BLOOD_Lymphoma	TBXAS1 →	+1.607	+0.305	<.001	<.001	3	7
BREAST	DCLRE1B →	+0.738	+0.586	<.001	<.001	3	7
CNS	SND1 →	+0.570	+0.466	.002	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060059 vs HIPK2 — BLOOD_Lymphoma

Explore this scatter interactively →