Regulation of protein glycosylation

pathway activity — cross-omics
GO:0060049Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of protein glycosylation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, EEF2, and RPS13, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCARPL5 →-0.298-0.053<.001<.00137
BRCAEEF2 →-0.315-0.066<.001<.00136
BRCARPS13 →-0.333-0.049<.001<.00136
BRCARPS3A →-0.197-0.049.001<.00136
BRCARPS8 →-0.434-0.061<.001<.00136
LSCCTOP1 →-0.292-0.045.003.00535
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration