Regulation of protein glycosylation

pathway activity — cross-omics
GO:0060049Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of protein glycosylation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1CC, LINC01340, and TM4SF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACPPP1CC →-0.322-0.310<.001<.00134
CCRCCLINC01340 →-0.215-0.643.007.00334
OVTM4SF1 →-1.280-0.737.005.00533
OVCEL →+0.751+0.746.008.00324
PDACPHAX →-0.356-0.266<.001<.00133
GBMPLAAT1 →-0.782-0.340<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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