Regulation of acrosome reaction

Across TCGA patient cohorts, RNA activity of the Regulation of acrosome reaction pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP9, GCC2, and EIF3H, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of acrosome reaction activity versus AKAP9 in CCRCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AKAP9 →	+0.150	+0.067	.004	.002	3	5
PDAC	GCC2 →	+0.115	+0.056	.002	<.001	3	5
BRCA	EIF3H →	-0.118	-0.038	.002	.009	3	4
GBM	VSNL1 →	-0.867	-0.039	<.001	.003	3	4
GBM	OPTN_S198 →	-0.662	-0.045	.002	.003	3	4
CCRCC	SETD3 →	-0.207	-0.088	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060046 vs AKAP9 — CCRCC

Explore this scatter interactively →