Regulation of acrosome reaction

Across TCGA patient cohorts, RNA activity of the Regulation of acrosome reaction pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK2B, HSPA12B, and BIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of acrosome reaction activity versus DIPK2B in HNSC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DIPK2B →	+0.364	+0.140	.003	<.001	3	5
HNSC	HSPA12B →	+0.855	+0.183	<.001	<.001	3	3
HNSC	BIN1 →	+1.099	+0.179	<.001	.001	3	3
HNSC	ANGPTL2 →	+0.678	+0.169	.002	.004	3	3
HNSC	BOC →	+0.741	+0.163	.001	<.001	3	3
HNSC	RSPO3 →	+0.324	+0.147	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060046 vs DIPK2B — HNSC

Explore this scatter interactively →