Regulation of acrosome reaction

Across TCGA cell cohorts, RNA activity of the Regulation of acrosome reaction pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR5, CUL1, and H3-3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLR5 grouped by Regulation of acrosome reaction-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TLR5 →	-0.191	-1.542	.007	<.001	3	5
BONE	CUL1 →	-0.495	-2.070	<.001	<.001	3	5
BONE	H3-3B →	-0.341	-1.428	.003	.004	3	4
BONE	TFPI →	+0.376	+1.574	<.001	<.001	3	4
LARGE_INTESTINE	MYLK →	-0.188	-1.387	.009	<.001	3	4
SKIN	ANKRD20A5P →	-0.190	-1.028	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLR5 by Regulation of acrosome reaction activity — BONE

Explore this box plot interactively →