Positive regulation of cardiac muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cardiac muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDK1, EML2, and HMGA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDK1 grouped by Positive regulation of cardiac muscle cell proliferation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PDK1 →	-0.732	-0.274	.001	.006	3	4
URINARY_TRACT	EML2 →	+1.470	+0.234	<.001	.002	3	3
BLOOD_Lymphoma	HMGA1 →	-1.260	-1.773	.001	<.001	3	3
BLOOD_Lymphoma	ALS2 →	+1.122	+0.194	.007	.006	2	4
SOFT_TISSUE	PRSS16 →	+1.752	+0.442	.001	.005	3	3
SOFT_TISSUE	ARHGAP24 →	-2.410	-0.435	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDK1 by Positive regulation of cardiac muscle cell proliferation activity — SKIN

Explore this box plot interactively →