Positive regulation of cardiac muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cardiac muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAT10, CISD1, and DDX50, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cardiac muscle cell proliferation activity versus NAT10 in LUNG_NSCLC_LUSC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NAT10 →	+0.630	+1.077	.003	.009	3	6
BLOOD_Myeloma	CISD1 →	+0.710	+1.142	.007	.005	3	6
BREAST	DDX50 →	+0.494	+0.734	.001	.007	2	6
BLOOD_Myeloma	TMPO →	+1.084	+1.504	.004	.001	3	5
BLOOD_Myeloma	HNRNPK →	+0.448	+1.416	.004	<.001	3	5
BLOOD_Myeloma	DNAJC9 →	+1.487	+1.728	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060045 vs NAT10 — LUNG_NSCLC_LUSC

Explore this scatter interactively →