Negative regulation of cardiac muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of cardiac muscle cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS1_S1393, MPRIP_S619, and NASP_S480, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle cell proliferation activity versus TNS1_S1393 in COAD (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TNS1_S1393 →	+0.778	+0.063	<.001	<.001	3	4
CCRCC	MPRIP_S619 →	+0.439	+0.068	.004	<.001	3	4
COAD	NASP_S480 →	-0.873	-0.050	<.001	.005	3	4
CCRCC	RACK1 →	-0.119	-0.047	.003	.006	3	4
COAD	TBC1D4_S666 →	+0.743	+0.051	<.001	<.001	3	4
BRCA	CARS1 →	-0.208	-0.033	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060044 vs TNS1_S1393 — COAD

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