Negative regulation of cardiac muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF738, TUSC1, and ARNTL, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF738 grouped by Negative regulation of cardiac muscle cell proliferation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF738 →	-1.508	-1.258	.004	.005	3	3
BREAST	TUSC1 →	-1.195	-0.915	.005	.005	3	3
KIDNEY	ARNTL →	-0.677	-0.991	.001	.009	3	3
KIDNEY	PFKFB1 →	+0.127	+1.044	.001	.005	3	3
KIDNEY	ALKBH3 →	-0.976	-1.506	.002	<.001	3	3
KIDNEY	CHST11 →	-1.605	-1.838	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF738 by Negative regulation of cardiac muscle cell proliferation activity — SOFT_TISSUE

Explore this box plot interactively →