Negative regulation of cardiac muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPH4, PPME1, and P3R3URF-PIK3R3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JPH4 grouped by Negative regulation of cardiac muscle cell proliferation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	JPH4 →	+0.305	+0.396	<.001	<.001	3	3
BLOOD_Myeloma	PPME1 →	-0.210	-0.313	.005	<.001	3	3
BLOOD_Myeloma	P3R3URF-PIK3R3 →	+0.275	+0.300	.003	.001	3	3
BLOOD_Myeloma	RBM46 →	+0.391	+0.409	<.001	.003	3	3
BLOOD_Myeloma	PRMT9 →	-0.262	-0.409	.003	.003	3	3
BREAST	SMPD2 →	-0.096	-0.386	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JPH4 by Negative regulation of cardiac muscle cell proliferation activity — BLOOD_Leukemia

Explore this box plot interactively →