Retina morphogenesis in camera-type eye

Across TCGA patient cohorts, RNA activity of the Retina morphogenesis in camera-type eye pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNF213, STAT2, and TYMP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina morphogenesis in camera-type eye activity versus RNF213 in BRCA (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNF213 →	-0.484	-0.023	<.001	.003	3	6
HNSC	STAT2 →	-0.376	-0.031	.001	.005	3	6
HNSC	TYMP →	-0.731	-0.042	<.001	<.001	3	6
LSCC	DOCK2 →	-0.422	-0.038	.002	<.001	3	6
HNSC	GBP1 →	-1.088	-0.043	<.001	<.001	3	6
GBM	MYO9B →	-0.225	-0.043	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060042 vs RNF213 — BRCA

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