Retina morphogenesis in camera-type eye

Across TCGA cell cohorts, RNA activity of the Retina morphogenesis in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPST1, NELFA, and GLIS3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TPST1 grouped by Retina morphogenesis in camera-type eye-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TPST1 →	-1.119	-1.168	.002	.003	3	4
BLOOD_Myeloma	NELFA →	+1.073	+1.087	<.001	.002	3	4
BONE	GLIS3 →	-3.108	-1.823	<.001	<.001	3	4
BONE	SIPA1L2 →	-2.200	-1.476	.003	.001	3	4
BONE	CD55 →	-3.562	-1.691	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ATF7IP →	+0.647	+0.688	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TPST1 by Retina morphogenesis in camera-type eye activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →