Retina morphogenesis in camera-type eye

Across TCGA cell cohorts, RNA activity of the Retina morphogenesis in camera-type eye pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS21, LPGAT1, and MED6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPS21 grouped by Retina morphogenesis in camera-type eye-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MRPS21 →	+0.223	+0.901	<.001	.006	3	3
LUNG_SCLC	LPGAT1 →	-0.190	-1.302	.007	<.001	3	3
LUNG_SCLC	MED6 →	-0.401	-1.525	.005	<.001	3	3
LUNG_SCLC	DNAI3 →	+0.202	+1.042	.006	.007	3	3
UPPER_AERODIGESTIVE_TRACT	MED23 →	-0.240	-1.851	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	DCSTAMP →	+0.213	+1.673	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPS21 by Retina morphogenesis in camera-type eye activity — SKIN

Explore this box plot interactively →