Retina morphogenesis in camera-type eye

Across TCGA cell cohorts, RNA activity of the Retina morphogenesis in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOSIP, NPIPB15, and RGPD6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina morphogenesis in camera-type eye activity versus NOSIP in BLOOD_Lymphoma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NOSIP →	+0.770	+0.985	<.001	.002	3	5
LUNG_SCLC	NPIPB15 →	-1.400	-0.809	.005	.008	3	4
BREAST	RGPD6 →	-0.957	-0.412	<.001	.007	3	4
BLOOD_Leukemia	NOVA1 →	-1.141	-0.774	.007	.007	3	3
BONE	FAM184A →	-1.792	-1.810	<.001	<.001	3	3
BONE	USP1 →	-1.101	-1.328	.003	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060042 vs NOSIP — BLOOD_Lymphoma

Explore this scatter interactively →