Retina development in camera-type eye

Across TCGA patient cohorts, RNA activity of the Retina development in camera-type eye pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID1, VCAN, and BBS7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina development in camera-type eye activity versus NID1 in HNSC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NID1 →	+0.553	+0.031	<.001	<.001	3	8
BRCA	VCAN →	+0.700	+0.020	<.001	<.001	3	8
UCEC	BBS7 →	+0.509	+0.045	<.001	<.001	3	7
PDAC	RNF213 →	-0.276	-0.019	.004	.006	3	7
OV	CNRIP1 →	+0.777	+0.039	<.001	<.001	3	7
BRCA	FERMT2 →	+0.455	+0.022	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060041 vs NID1 — HNSC

Explore this scatter interactively →