Retina development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Retina development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELENOM, MICAL2, and TPST1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SELENOM grouped by Retina development in camera-type eye-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SELENOM →	-2.194	-1.416	<.001	.007	3	5
OVARY	MICAL2 →	-1.801	-1.117	.002	.003	2	5
UPPER_AERODIGESTIVE_TRACT	TPST1 →	-1.209	-1.249	.007	.007	3	4
OVARY	SMIM12 →	-0.637	-1.263	.002	<.001	3	4
BONE	CD70 →	-3.867	-0.996	<.001	.005	3	4
BREAST	B4GALT7 →	-0.447	-0.590	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SELENOM by Retina development in camera-type eye activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →