Retina development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Retina development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL1, THNSL1, and RAET1G, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina development in camera-type eye activity versus GRHL1 in BONE (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GRHL1 →	-0.895	-0.314	<.001	<.001	3	5
OESOPHAGUS	THNSL1 →	-0.891	-0.138	<.001	.008	3	4
OESOPHAGUS	RAET1G →	+1.449	+0.218	.006	.009	2	5
SOFT_TISSUE	ATP7B →	-1.360	-0.317	.002	.001	3	4
BLOOD_Leukemia	MPST →	-1.855	-0.198	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SH3BGRL3 →	+0.963	+0.217	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060041 vs GRHL1 — BONE

Explore this scatter interactively →