Pericardium development

Across TCGA patient cohorts, RNA activity of the Pericardium development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AGT, HOOK3, and ANGPTL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pericardium development activity versus AGT in OV (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AGT →	+0.641	+0.066	.005	.004	3	5
UCEC	HOOK3 →	+0.269	+0.049	<.001	.002	3	5
UCEC	ANGPTL2 →	+0.784	+0.077	<.001	<.001	3	5
UCEC	LAMB2 →	+0.502	+0.057	.007	.003	3	5
BRCA	TNS1_Y1404 →	+0.602	+0.038	<.001	.003	3	5
OV	SNTB2 →	+0.266	+0.052	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060039 vs AGT — OV

Explore this scatter interactively →